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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: J Antibiot (Tokyo). 2020 Mar 4;73(6):392–409. doi: 10.1038/s41429-020-0288-3

Figure 1: Effect of the nitro group position and alkyl substitution on the anticlostridial activity of nitroim idazoles and nitrothiazoles.

Figure 1:

5-nitroimidazoles were found to be more potent than 2-nitroimdazle. Contrarily, variation in the alkyl substitution of 5-nitroimdazole did not significantly affect anticlostridial activity. Additionally, Increasing the size of the substitution at position 2 of the nitrothiazole ring increased the MIC from 0.25 μM in the case of nithiamide to 2 μM in case of nitazoxanide. MIC values are against C. difficile NAP07 and are expressed in μM.