Table 1:
Active drugs “hits” identified from initial screening against C. difficile NAP07
| Compound name | Chemical structure | MIC (μM) | Main use | |
|---|---|---|---|---|
| 1 | Ronidazole |  |
0.06 | Anthelmintic |
| 2 | Phenylmercuric acetate |  |
0.25 | Antifungal, antimicrobial |
| 3 | Ornidazole |  |
0.25 | Anthelmintic |
| 4 | Dimetridazole |  |
0.25 | Anthelmintic |
| 5 | Nithiamide |  |
0.25 | Antiprotozoal (trichomonas). |
| 6 | Closantel |  |
0.25 | Anthelmintic. |
| 7 | Bithionate sodium |  |
0.50 | Anthelmintic, antiseptic |
| 8 | Secnidazole |  |
0.50 | Anthelmintic, antitrichomonas |
| 9 | Oxyclozanide |  |
0.50 | Anthelmintic |
| 10 | Tinidazole |  |
0.50 | Antiprotozoal |
| 11 | Metoprolol tartrate |  |
1 | Antihypertensive, antianginal |
| 12 | Miconazole nitrate |  |
1 | Antifungal (topical) |
| 13 | Metoclopramide hydrochloride |  |
2 | Antiemetic |
| 14 | Chloroquine diphosphate |  |
2 | Anthelmintic, antirheumatic, intercalating agent |
| 15 | Nitazoxanide |  |
2 | Anthelmintic |
| 16 | Benznidazole (n-benzyl-2-nitro-1h-imidazole-1-acetamide) |  |
2 | Antiprotozoal (trypanosoma) |
| 17 | Bithionol oxide (2,2′-sulfinyl-bis(4,6-dichlorophenol)) |  |
2 | Anthelmintic |
| 18 | Nifursol |  |
4 | Anthelmintic |
| 19 | Butoconazole |  |
4 | Antifungal |
| 20 | Broxaldine |  |
4 | Anthelmintic, antifungal |
| 21 | Oxiconazole nitrate |  |
4 | Antifungal |
| 22 | Clotrimazole |  |
8 | Antifungal |
| 23 | Diethylstilbestrol |  |
8 | Estrogen |
| 24 | Methylthiouracil |  |
8 | Antithyroid agent |
| 25 | Econazole nitrate |  |
8 | Antifungal |
| 26 | Diclazuril |  |
8 | Coccidiostat |
| 27 | Niclosamide |  |
8 | Anthelmintic, teniacide |
| 28 | Triclabendazole |  |
8 | Anthelmintic |
| 29 | Dichlorophene |  |
8 | Anthelmintic (cestodes) |
| 30 | Sulconazole |  |
8 | Antifungal |
| 31 | Tioconazole |  |
8 | Antifungal (topical) |
| 32 | Puromycin |  |
8 | Antineoplastic |
| 33 | Sanguinarium chloride |  |
16 | Antineoplastic, antiplaque agent |
| 34 | Norgestimate |  |
16 | Progestin |
| 35 | Estradiol valerate |  |
16 | Estrogen |
| 36 | Methylprednisolone |  |
16 | Anti-inflammatory, glucocorticoid |
| 37 | Proglumide |  |
16 | Anticholinergic and cholecystokinin antagonist |
| 38 | Sulconazole nitrate |  |
16 | Antifungal |
| 39 | Tretinoin |  |
16 | Keratolytic, antiacne, antineoplastic |
| 40 | Chloroxine |  |
16 | Chelating agent, antiseborrheic |
| 41 | Benzalkonium chloride |  |
16 | Preservative |
| 42 | Prednicarbate |  |
16 | Anti-inflammatory, glucocorticoid |
| 43 | Teniposide |  |
16 | Antineoplastic |
| 44 | Bifonazole |  |
16 | Antifungal, calmodulin antagonist |
| 45 | Benzbromarone |  |
16 | Uricosuric |
| 46 | Toremifene citrate |  |
16 | Antineoplastic, antiestrogen |
| 47 | Quinaldine blue (pinacyanol chloride) |  |
16 | Antineoplastic |
| 48 | Dithiazanine iodide |  |
16 | Anthelmintic (nematodes) |
| 49 | Rose bengal |  |
16 | Diagnostic aid (corneal trauma indicator). |
| 50 | Alprenolol hydrochloride |  |
16 | Antihypertensive |