Table 4:
MICs (μg/mL) of the active compounds against human normal gut flora
| Bacterial Strain | Strain ID | Nitroimidazole | Imidazole antifungals | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ronidazole | Dimetridazole | Ornidazole | Tinidazole | Miconazole | Econazole | Tioconazole | Butoconazole | Clotrimazole | ||
| Lactobacillus casei | ATCC-334 | >640 | >907 | >583 | >518 | 308 | 335 | 330 | 311 | 371 |
| Lactobacillus acidophilus | ATCC-314 | 640 | >907 | >583 | >518 | 308 | 335 | >330 | >311 | 371 |
| Bifidobacterium bifidum | ATCC-11863 | ≤5 | ≤7 | ≤5 | 32 | 10 | 21 | 21 | 19 | 23 |
| Bifidobacterium breve | ATCC-15700 | ≤5 | 227 | 146 | 518 | 38 | 42 | 41 | 39 | 46 |
| Bifidobacterium longum | HM-845 | ≤5 | ≤7 | 36 | 16 | 38 | 42 | 41 | 5 | 46 |
| Bifidobacterium breve | HM-856 | >640 | >907 | >583 | >518 | 38 | 42 | >330 | 10 | 46 |
| Bacteroides fragilis | HM-711 | ≤5 | 28 | ≤5 | ≤4 | 38 | 42 | 5 | 10 | 46 |
| Bacteroides fragilis | HM-709 | ≤5 | 28 | ≤5 | ≤4 | 19 | 21 | ≤3 | 10 | 46 |
| Lactobacillus crispatus | HM-371 | 640 | 907 | >583 | >518 | 308 | 335 | >330 | >311 | 371 |
| Lactobacillus gasseri | HM-407 | 320 | 907 | >583 | >518 | 308 | 335 | >330 | >311 | 371 |
| Escherichia coli | ATCC-35150 | 640 | 113 | >583 | >518 | >308 | >335 | >330 | 78 | >371 |
| Escherichia coli | 1411 | 640 | 113 | >583 | >518 | >308 | >335 | >330 | 78 | >371 |
| Enterococcus faecalis -- TX0104 | HM-201 | 640 | 454 | >583 | >518 | 38 | 42 | >330 | 19 | >371 |
| Strain | Strain ID | Salicylanilides | Miscellaneous | Vancomycin | Metronidazole | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Closantel | Oxyclozanide | Niclosamide | Nitazoxanide | Dichlorophene | Triclabendazole | Nithiamide | ||||
| Lactobacillus casei | ATCC-334 | 193 | 80 | 196 | >417 | >476 | >356 | >684 | >88 | >748 |
| Lactobacillus acidophilus | ATCC-314 | 97 | 40 | >391 | >417 | >476 | >356 | >684 | 0.7 | >47 |
| Bifidobacterium bifidum | ATCC-11863 | ≤1.5 | 40 | ≤3 | ≤3 | 30 | 11 | ≤5 | 0.7 | 5.8 |
| Bifidobacterium breve | ATCC-15700 | ≤1.5 | 10 | ≤3 | ≤3 | 30 | 22 | ≤5 | 2.8 | 47 |
| Bifidobacterium longum | HM-845 | ≤1.5 | ≤2.5 | ≤3 | 52 | 30 | 5.5 | ≤5 | 0.3 | 23 |
| Bifidobacterium breve | HM-856 | 3 | 40 | ≤3 | 26 | 30 | 22 | ≤5 | 0.3 | >748 |
| Bacteroides fragilis | HM-711 | 3 | 5 | 6 | 26 | 30 | 44 | 43 | 88 | ≤5.8 |
| Bacteroides fragilis | HM-709 | 3 | 5 | ≤3 | 26 | 30 | 22 | 11 | 44 | ≤5.8 |
| Lactobacillus crispatus | HM-371 | 12 | >319 | 49 | 417 | 476 | >356 | 342 | 1.4 | >748 |
| Lactobacillus gasseri | HM-407 | 12 | >319 | 49 | 417 | 476 | >356 | 342 | 1.4 | >748 |
| Escherichia coli | ATCC-35150 | >193 | >319 | >391 | >417 | >476 | >356 | >684 | ND | ND |
| Escherichia coli | 1411 | 193 | >319 | >391 | >417 | >476 | >356 | >684 | ND | ND |
| Enterococcus faecalis -- TX0104 | HM-201 | 24 | >319 | >391 | 26 | 59 | 22 | 11 | >88 | ND |
| Enterococcus faecalis -- TX1322 | HM-202 | 24 | >319 | >391 | 26 | 59 | 11 | 11 | 0.7 | ND |
ND= Not detected