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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Alcohol Clin Exp Res. 2020 Mar 27;44(5):1025–1036. doi: 10.1111/acer.14318

Figure 1. Mifepristone reduced binge-like ethanol intake and BECs in HDID-1 mice.

Figure 1.

HDID-1 mice (n = 7–11/sex/dose) were tested in a 2-day ethanol DID, followed in subsequent weeks with water DID and saccharin DID. (a) The 50 mg/kg and 100 mg/kg doses of mifepristone significantly reduced ethanol intake (g/kg) in the 4-hour drinking session on Day 2, relative to vehicle. (b) The 50 mg/kg dose of mifepristone significantly reduced BECs relative to vehicle. In contrast, no dose of mifepristone reduced (c) water or (d) saccharin intake (ml/kg) relative to vehicle. BEC = blood ethanol concentration. Dotted line visually represents 0.8 mg/ml, the level of intoxication. All data collapsed on sex. (* = p < 0.05, *** = p < 0.001, **** = p < 0.0001)