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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Ophthalmol Retina. 2019 Nov 18;4(5):510–520. doi: 10.1016/j.oret.2019.11.010

Figure 2. Allelic heterogeneity is associated with myopia but not with clinical severity.

Figure 2.

(A) The distribution of clinical severity, and (B) the distribution of myopia and hyperopia of greater than 0.5 diopters, was compared for mutations in exons 1–14 vs. ORF15 and mutations that are predicted to be null vs. non-null. Using chi-squared tests, the distributions of clinical severity (A) were not significantly different between mutation types (p= 0.728 and p= 0.937, respectively). Myopia (B) was significantly associated with mutations in Exons 1–14 compared to mutations in ORF15 (*p=0.01), but was not associated with null compared to non-null variants (p=0.30).