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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Ophthalmol Retina. 2019 Nov 18;4(5):510–520. doi: 10.1016/j.oret.2019.11.010

Figure 3. XCI ratio is associated with clinical severity.

Figure 3.

A) Extreme skewing of the XCI ratio towards inactivation of the normal RPGR allele is associated with the severe phenotype (*p= 0.002). B) The probability of being mildly, moderately, or severely affected is plotted using multinomial regression as a function of the percent of cells with normal RPGR, inferred from the XCI ratio. The vertical distance represents the probability of each disease severity category for a specific XCI blood ratio. C) The change in each clinical parameter as the XCI ratio doubles is graphed as a percentage of the interquartile range (IQR) to normalize data from different scales, and in some cases the direction is reversed so that larger values indicate worse visual function. DAT= dark adaptation threshold, AMP= amplitude, IT= implicit time.