First derivatives of DHEAS on age for females (a, n = 31) and males (b, n = 22). Horizontal line at zero added to highlight adrenarche (females = 2.61 [1.75–3.44] years, males = 2.85 [2.34–3.32 years]), defined as the earliest age at which the smooth of DHEAS on age changes from negative to positive. DHEAS, dehydroepiandrosterone-sulfate