Table 3.
Tests of COPD x SNP interaction on lung cancer risk for the 60 validated SNPs in individuals without COPD
| SNP | Gene | CHR | Position | COPD × SNP interaction p value |
Pooled risk model results | ||
|---|---|---|---|---|---|---|---|
| OR* | 95% CI | p value | |||||
| exm69478 | ASB17 | 1 | 76397972 | 0.156 | 1.29 | (1.1,1.5) | 0.0014 |
| JHU_1.108497389 | VAV3 | 1 | 108497390 | 0.029 | 0.72 | (0.58,0.89) | 0.0022 |
| rs3754293 | LAMTOR2 | 1 | 156024373 | 0.219 | 0.8 | (0.69,0.93) | 0.0028 |
| exm113346 | SPTA1 | 1 | 158645965 | <0.001 | 6.46 | (2.37,17.63) | 0.0003 |
| rs2230779 | TRAF5 | 1 | 211533352 | 0.534 | 1.59 | (1.18,2.14) | 0.0024 |
| rs10929693 | ATP6V1C2 | 2 | 10863267 | 0.435 | 0.8 | (0.69,0.93) | 0.0032 |
| exm175467 | APOB | 2 | 21225281 | 0.187 | 1.2 | (1.02,1.43) | 0.0316 |
| newrs676210 | APOB | 2 | 21231524 | 0.183 | 1.21 | (1.02,1.43) | 0.0299 |
| rs3749096 | EDAR | 2 | 109512428 | 0.044 | 1.34 | (1.1,1.63) | 0.0033 |
| rs13418730 | WIPF1 | 2 | 175540594 | 0.048 | 0.68 | (0.52,0.89) | 0.0046 |
| rs7583875 | AP1S3 | 2 | 224665694 | 0.062 | 0.8 | (0.7,0.92) | 0.0016 |
| JHU_3.18396523 | SATB1 | 3 | 18396524 | 0.127 | 0.35 | (0.2,0.6) | 0.0001 |
| rs80069959 | KCNH8 | 3 | 19223049 | 0.069 | 0.58 | (0.4,0.84) | 0.0040 |
| JHU_3.119275362 | CD80 | 3 | 119275363 | 0.019 | 0.53 | (0.36,0.77) | 0.0009 |
| rs953239 | TRPC1 | 3 | 142446205 | 0.003 | 1.23 | (1.07,1.41) | 0.0036 |
| rs7623154 | PIK3CA | 3 | 178921158 | 0.020 | 1.25 | (1.07,1.46) | 0.0055 |
| JHU_5.16912953 | MYO10 | 5 | 16912954 | 0.029 | 2.24 | (1.27,3.94) | 0.0051 |
| JHU_5.35873123 | IL7R | 5 | 35873124 | 0.187 | 0.6 | (0.43,0.84) | 0.0034 |
| rs7726469 | CAMK4 | 5 | 110586438 | 0.020 | 0.76 | (0.65,0.9) | 0.0015 |
| rs12153148 | KLHL3 | 5 | 136964764 | 0.066 | 0.74 | (0.62,0.88) | 0.0006 |
| rs3777376 | KLHL3 | 5 | 136965249 | 0.042 | 0.73 | (0.61,0.87) | 0.0005 |
| rs7774142 | LY86 | 6 | 6642058 | 0.027 | 1.3 | (1.12,1.5) | 0.0007 |
| exm-rs3827784 | LY86 | 6 | 6642405 | 0.031 | 1.31 | (1.12,1.52) | 0.0005 |
| JHU_6.137043810 | MAP3K5 | 6 | 137043811 | 0.016 | 2.19 | (1.23,3.89) | 0.0075 |
| rs56247201 | PARK2 | 6 | 162702092 | 0.191 | 0.5 | (0.33,0.74) | 0.0006 |
| rs35537854 | RPS6KA2 | 6 | 167072030 | 0.128 | 0.6 | (0.42,0.85) | 0.0041 |
| JHU_7.30352063 | ZNRF2 | 7 | 30352064 | 0.001 | 0.15 | (0.04,0.53) | 0.0033 |
| JHU_7.30393775 | ZNRF2 | 7 | 30393776 | 0.062 | 0.29 | (0.14,0.62) | 0.0014 |
| exm689348 | TNFRSF10A | 8 | 23049292 | 0.298 | 0.75 | (0.62,0.92) | 0.0047 |
| rs73241640 | NRG1 | 8 | 31932616 | 0.031 | 0.39 | (0.24,0.63) | 0.0002 |
| rs11776203 | NRG1 | 8 | 32419119 | 0.003 | 0.76 | (0.63,0.92) | 0.0039 |
| JHU_8.32431713 | NRG1 | 8 | 32431714 | 0.446 | 0.42 | (0.24,0.74) | 0.0029 |
| rs1014306 | DAPK1 | 9 | 90157451 | 0.317 | 1.33 | (1.14,1.54) | 0.0002 |
| rs12378686 | DAPK1 | 9 | 90163570 | 0.547 | 1.3 | (1.1,1.52) | 0.0018 |
| JHU_9.90198587 | DAPK1 | 9 | 90198588 | 0.152 | 0.58 | (0.4,0.82) | 0.0024 |
| rs10995319 | PRKG1 | 10 | 52762887 | 0.125 | 1.32 | (1.09,1.6) | 0.0045 |
| rs7904024 | PRKG1 | 10 | 52841790 | 0.022 | 1.28 | (1.11,1.48) | 0.0007 |
| JHU_10.83841723 | NRG3 | 10 | 83841724 | 0.415 | 2.87 | (1.4,5.86) | 0.0038 |
| rs74153420 | BMPR1A | 10 | 88628433 | 0.287 | 2.4 | (1.33,4.33) | 0.0038 |
| JHU_10.93222022 | HECTD2 | 10 | 93222023 | 0.486 | 1.46 | (1,2.11) | 0.0481 |
| JHU_10.123313013 | FGFR2 | 10 | 123313014 | 0.020 | 1.49 | (1.17,1.91) | 0.0014 |
| rs548142 | DYNC2H1 | 11 | 103315520 | 0.048 | 0.75 | (0.65,0.86) | 0.0001 |
| JHU_12.6438144 | TNFRSF1A | 12 | 6438145 | 0.016 | 1.83 | (1.3,2.58) | 0.0005 |
| JHU_12.26512936 | ITPR2 | 12 | 26512937 | 0.011 | 3.4 | (1.48,7.86) | 0.0041 |
| rs61971164 | STK24 | 13 | 99190397 | 0.072 | 0.73 | (0.61,0.88) | 0.0008 |
| rs17565502 | TNFSF13B | 13 | 108954304 | 0.061 | 1.26 | (1.08,1.47) | 0.0039 |
| JHU_14.23313974 | MMP14 | 14 | 23313975 | 0.011 | 0.54 | (0.35,0.82) | 0.0038 |
| rs78656887 | PSMC1 | 14 | 90734095 | 0.018 | 0.48 | (0.31,0.76) | 0.0016 |
| rs12441042 | TLN2 | 15 | 62946064 | 0.085 | 0.79 | (0.68,0.92) | 0.0019 |
| rs74318887 | MEF2A | 15 | 100229061 | 0.027 | 0.46 | (0.29,0.74) | 0.0012 |
| rs76272325 | PSMB6 | 17 | 4699845 | 0.172 | 0.5 | (0.34,0.74) | 0.0004 |
| JHU_17.5413392 | NLRP1 | 17 | 5413393 | 0.055 | 0.79 | (0.68,0.93) | 0.0033 |
| JHU_17.40648111 | ATP6V0A1 | 17 | 40648112 | 0.003 | 1.83 | (1.33,2.51) | 0.0002 |
| rs12949223 | CD300LD | 17 | 72589264 | 0.246 | 1.24 | (1.07,1.44) | 0.0050 |
| JHU_18.21773860 | OSBPL1A | 18 | 21773861 | 0.115 | 2.78 | (1.49,5.17) | 0.0012 |
| rs11082490 | SIGLEC15 | 18 | 43412628 | <0.001 | 1.53 | (1.27,1.84) | <0.0001 |
| rs58993112 | MALT1 | 18 | 56412784 | 0.159 | 1.35 | (1.11,1.64) | 0.0023 |
| exm2253611 | PDE4A | 19 | 10546771 | 0.029 | 1.25 | (1.08,1.45) | 0.0027 |
| rs9676881 | KEAP1 | 19 | 10596780 | 0.008 | 1.32 | (1.14,1.53) | 0.0002 |
| rs2898449 | MX1 | 21 | 42814495 | 0.063 | 0.69 | (0.54,0.87) | 0.0020 |
*
Logistic model adjusted for age, gender, African ancestry score and pack years