Table 5.
Relation of UPCR quartiles and log-transformed UPCR to progression to dialysis, overall and cardiovascular mortality using multivariate forward Cox proportional hazards model in study patients
| Parameters | Commencement of dialysis | Overall mortality | Cardiovascular mortality | |||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | |
| Model 1 | ||||||
| Quartile 1 of UPCR | Reference | Reference | Reference | |||
| Quartile 2 of UPCR | 3.476 (0.769-15.708) | 0.105 | 1.844 (0.626-5.428) | 0.267 | 3.853 (0.428-34.713) | 0.229 |
| Quartile 3 of UPCR | 6.731 (1.531-29.600) | 0.012 | 3.452 (1.179-10.109) | 0.024 | 11.741 (1.422-96.935) | 0.022 |
| Quartile 4 of UPCR | 6.639 (1.466-30.075) | 0.014 | 4.845 (1.805-12.999) | 0.002 | 12.974 (1.642-102.481) | 0.015 |
| Model 2 | ||||||
| UPCR (log per 1 mg/g) | 2.538 (1.375-4.685) | 0.003 | 2.292 (1.329-3.953) | 0.003 | 3.195 (1.393-7.325) | 0.006 |
Values expressed as hazard ratio and 95% confidence interval (CI). Abbreviations are the same as in Table 1.
Multivariate model 1: adjusted for age, gender, smoking, diabetes mellitus, hypertension, coronary artery disease, cerebrovascular disease, systolic and diastolic blood pressures, body mass index, fasting glucose, log-transformed triglyceride, total cholesterol, hemoglobin, baseline CKD stage, total calcium, phosphorous, calcium-phosphorous product, uric acid, PTH, log-transformed UPCR, ACEI/ARB antihypertensive drug and calcium-based phosphate binders use.
Multivariate model 2: adjusted for age, gender, smoking, diabetes mellitus, hypertension, coronary artery disease, cerebrovascular disease, systolic and diastolic blood pressures, body mass index, fasting glucose, log-transformed triglyceride, total cholesterol, hemoglobin, baseline CKD stage, total calcium, phosphorous, calcium-phosphorous product, uric acid, PTH, log-transformed UPCR, ACEI/ARB antihypertensive drug and calcium-based phosphate binders use.