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. 2020 Apr 27;16(11):2001–2013. doi: 10.7150/ijbs.43825

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Nicotine modulate the CTSB enzyme activity of lysosome through autophagy impairment, which reversed by cilostazol. (A) Nicotine treatment decreased the enzyme activity of CTSB in dose-dependent manner, Rap, PP242 and Baf A1 were chosen as controls, and cilostazol could relieve this effect (B). mRNA level of CTSB kept unchanged after the nicotine treatment (C), while the protein level of CTSB and, pro-CTSB showed increase under nicotine stimulation (D). (****, p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.05, n = 3).