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. 2020 Apr 27;16(11):2001–2013. doi: 10.7150/ijbs.43825

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P38MAPK and JNK were responsible for nicotine induced autophagy impairment and caused cardiomyocytes hypertrophy. (A) JNK activation and the expression of autophagy related proteins decreased after pretreatment with the specific inhibitor of JNK SP600125. (B) P38MAPK phosphorylation, LC3-II and p62 protein levels were reduced after treatment with p38MAPK specific inhibitor SB203580. Autophagy flux impairment (C) were also reversed by NAC, SP100625 and SB203580. (Scale bar=20 μm) The specific inhibitor of (D) JNK and (E) p38MAPK pretreatment reversed nicotine induced cardiomyocytes hypertrophy and increased the CTSB activity (F). (****, p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.05, n = 3).