Table 2.

Summary of pharmacokinetic parameters of total radioactivity and unchanged rucaparib

Parameter	Total radioactivity in blood and plasma, mean ± SD			Rucaparib concentration in plasma, mean ± SD
	Plasma	Blood	Blood to plasma ratio
Cmax, ng Eq/mL or ng/mL	880 ± 309	882 ± 355	1.00 ± 0.12	428 ± 154
tmax, ha	4 (0.933–8.00)	4 (0.933–8.00)	–	4 (0.933–8.00)
AUC0-t, ng Eq h/mL or ng h/mL	24,100 ± 8580	18,100 ± 5460	–	8950 ± 3230
AUC0-inf, ng Eq h/mL or ng h/mL	30,000 ± 7810	25,500 ± 5510	0.781 ± 0.041	9340 ± 3480
t1/2, h	30.4 ± 8.89	28.3 ± 8.49	–	25.9 ± 10.1
CL/F, L/h	19.6 ± 4.83	22.6 ± 2.22	–	73.9 ± 45.5
Vd/F, L	814 ± 129	911 ± 246	–	2300 ± 490

^at_max presented as median (range)

AUC_0-inf area under the concentration-time curve from time zero to infinity, AUC_0-t area under the concentration time curve from time zero to time of last measurable concentration, CL/F apparent clearance, C_max maximum concentration, SD standard deviation, t_1/2 terminal half-life, t_max time to maximum concentration, Vd/F apparent volume of distribution