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Primary and higher order structure of representative HLX02, CN-Herceptin®, and EU-Herceptin®. a Peptide maps of tryptic digests; mass spectra of b intact mAb and c reduced HC; d DSC thermograms; e far-UV CD spectra and f near-UV CD spectra. The mass spectra of the RPs in diagrams b and c are plotted in the order of expiry date. CD circular dichroism, CN China-sourced, DSC differential scanning calorimetry, EU Europe-sourced, HC heavy chain, mAb monoclonal antibody, RP reference product
