Fig. 5.

The ability of compound 22 to induce generation of oxidative stress in A375 cells. Cells were exposed to 100 μM of compound 22 for 24, 48 and 72 h and monitored by means of (a) flow cytometry in addition to being quantitated as (b) ROS fold induction. Data shown are means ± SD of 3 replicates from three independent experiments. Asterisks (***) denote statistical significance at p < 0.001 when compared to the respective controls after of exposure