Table 4.
Association of MTHFR SNPs with GDM Risk
| SNPs | Loci | GDM, n (%) | Non-GDM, n (%) | Adjusted Modela | |
|---|---|---|---|---|---|
| OR (95% CI) | P | ||||
| Genotype | CC | 8 (12.0) | 56(18.7) | 1.000 | |
| CT | 35(52.2) | 151(50.5) | 2.162(0.842–5.551) | 0.109 | |
| TT | 24(35.8) | 92(30.8) | 2.391(0.875–6.529) | 0.089 | |
| Dominant model | CC | 8 (12.0) | 56(18.7) | ||
| CT+TT | 59(88.0) | 243(81.3) | 2.241(0.901–5.578) | 0.083 | |
| Additive model | CT | 35(52.2) | 151(50.5) | ||
| CC+TT | 32(47.8) | 148(49.5) | 0.822(0.452–1.497) | 0.522 | |
Note: aAdjustments for age, physical activity, BMI, parity, family history of diabetes, use of FA supplements, HOMA-IR, C-reactive protein, hemoglobin, vitamin B12, and serum homocysteine.