Table 1.
Published Multimodal Approaches Proposed for Face or Neck Rejuvenation
| Face | Neck (±Decolletage) |
|---|---|
| RCTs (n Patients) | |
| HA filler + RF vs HA filler (n = 10)57 | |
| BoNTx + HA filler vs BoNTx (n = 20)58 | |
| BoNTx + HA filler vs BoNTx + HA filler + cosmetic treatment (n = 20)59 | |
| BoNTx + HA filler vs BoNTx vs HA filler (n = 90)60 | |
| Non-Randomized Studies and Case Reports (n Participants) | |
| HA filler + RF + (n = 1)61 | BoNTx + HA filler + MFU-V (or CaHA) (n = 10)56 |
| BoNTx + HA filler + laser resurfacing (n = 1)62 | BoNTx + HA filler + IFU (n = 12)63 |
| BoNTx + CaHA + HA filler + injectable PLLA (n = 2)20 | CaHA + MFU-V (n = 47)64 |
| BoNTx + CaHA + HA filler + MFU-V (n = 101)65 | BoNTx + CaHA + HA filler + MFU-V (n = 101)65 |
| BoNTx + HA filler (n = 60)66 | |
| Bimatoprosta + BoNTx + HA filler (n = 116)55 | |
| Reviews | |
| BoNTx + HA filler + various EBDs (laser, IPL, MFUS, FMR)22 | Various techniquesb 52 |
| BoNTx or HA fillers + IPL + lasers (ablative and non-ablative) + RF67 | |
Notes: aBimatoprost 0.3% ophthalmic solution; bATX-101, ablative and non-ablative fractional lasers, BoNTx, cryolipolysis, HA fillers, IPL, laser lipolysis, liposuction, MFU-V, monopolar RF.
Abbreviations: BoNTx, botulinum neurotoxin; CaHA, calcium hydroxyapatite; FMR, fractional microneedle radiofrequency; HA, hyaluronic acid; IFU, intensity focused ultrasound; IPL, intense pulsed light; MFUS, micro-focused ultrasound; MFU-V, micro-focused ultrasound with visualization; PLLA, poly-L-lactic acid; RCT, randomized controlled trial; RF, radiofrequency; US, ultrasound.