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. 2020 May 5;12:3131–3144. doi: 10.2147/CMAR.S243869

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© 2020 Yang et al.

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Restoration of IRS4 can reverse the inhibitory impact of the LINC00173 knockdown on the malignant behavior of melanoma cells. (A) The protein level of IRS4 in A375 and HT144 cells transfected with either pcDNA3.1-IRS4 or the empty pcDNA3.1 vector was tested by Western blotting. (B–F) LINC00173-deficient A375 and HT144 cells were next transfected with either pcDNA3.1-IRS4 or pcDNA3.1. After cotransfection, proliferation, apoptosis, cell cycle distribution, migration, and invasion were evaluated via the CCK-8 assay, flow-cytometric analysis, and migration and invasion assays, respectively. *P < 0.05 and **P < 0.01.