Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism of Antifungal Resistance by C. auris
| Antifungal | Resistance Mechanism | References |
|---|---|---|
| Polyenes | Mutations, 5 SNPs in different genome loci | [28,56] |
| Azoles | Point mutations in the lanosterol 14 α-demethylase (ERG11) gene | [21,24,57] |
| ERG 11 up-regulation due to mutation in Upc2 TF | ||
| Up-regulation of efflux pump genes | ||
| Nucleoside analogs | Amino acid substitution (F211) in FUR1 | [58] |
| Echinocandin | Mutation in FKS1/2 gene | [10] |
