Table 1.
The In Vitro Antimicrobial Activity of Compounds 4–18 Showing the Inhibition Zones (IZ) and Minimum Inhibition Concentration (MIC) Against the Selected Strains
| Compound Code | Mean Diameter of Inhibition Zone (mm) and Minimal Inhibitory Concentrations (MIC) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B. subtilis (ATCC 6633) | S. aureus (ATCC 29,213) | E. coli (ATCC 25,922) | P. aeruginosa (ATCC 27,853) | C. albicans (ATCC 10,231) | MRSA | |||||||
| IZ | MIC | IZ | MIC | IZ | MIC | IZ | MIC | IZ | MIC | IZ | MIC | |
| 4 | 16 ± 0.01 | 2.50 | 13 ± 0.04 | 5.00 | NA | – | NA | – | 14 ± 0.05 | 2.50 | NA | – |
| 5 | 25 ± 0.07 | 2.50 | 22 ± 0.31 | 1.56 | 14 ± 0.23 | 10.00 | 15 ± 0.21 | 20.00 | 19 ± 0.05 | 5.00 | 20 ± 0.18 | 10.00 |
| 6 | 16 ± 0.10 | 15.63 | 14 ± 0.03 | 31.25 | 15 ± 0.31 | 5.00 | 17 ± 0.13 | 7.50 | 20 ± 0.25 | 3.91 | NA | – |
| 7 | 20 ± 0.21 | 1.25 | 15 ± 0.07 | 2.50 | 12 ± 0.15 | 20.00 | 14 ± 0.03 | 15.63 | 22 ± 0.08 | 10.00 | 10 ± 0.02 | 7.81 |
| 8 | 26 ± 0.16 | 6.31 | 23 ± 0.09 | 12.50 | NA | – | NA | – | 24 ± 0.16 | 6.31 | 19 ± 0.01 | 20.00 |
| 9 | 22 ± 0.16 | 2.50 | 18 ± 0.12 | 5.00 | 30 ± 0.28 | 1.25 | 25 ± 0.14 | 2.50 | 21 ± 0.14 | 5.00 | 14 ± 0.13 | 15.63 |
| 10 | 16 ± 0.04 | 7.81 | 12 ± 0.04 | 15.63 | NA | – | NA | – | NA | – | NA | – |
| 11 | 28 ± 0.13 | 1.25 | 26 ± 0.31 | 2.50 | 14 ± 0.14 | 5.00 | 16 ± 0.11 | 20.00 | 18 ± 0.19 | 10.00 | 22 ± 0.09 | 10.00 |
| 12 | 21 ± 0.20 | 1.95 | 24 ± 0.26 | 10.00 | 13 ± 0.12 | 10.00 | 15 ± 0.16 | 12.51 | 21 ± 0.05 | 7.81 | 20 ± 0.21 | 7.81 |
| 13 | 35 ± 0.14 | 0.49 | 33 ± 0.17 | 1.25 | 12 ± 0.17 | 1.25 | 14 ± 0.12 | 10.00 | 26 ± 0.30 | 5.00 | 28 ± 0.16 | 5.00 |
| 14 | 24 ± 0.02 | 2.50 | 27 ± 0.21 | 3.90 | 16 ± 0.01 | 5.00 | 20 ± 0.21 | 7.81 | 20 ± 0.21 | 6.31 | 24 ± 0.13 | 12.50 |
| 15 | 20 ± 0.04 | 7.81 | 16 ± 0.01 | 15.63 | 13 ± 0.04 | 15.63 | 18 ± 0.12 | 10.00 | 14 ± 0.11 | 3.80 | 12 ± 0.09 | 31.25 |
| 16 | 36 ± 0.11 | 0.31 | 35 ± 0.09 | 0.62 | 32 ± 0.20 | 1.25 | 25 ± 0.11 | 2.50 | 27 ± 0.12 | 1.25 | 29 ± 0.05 | 5.00 |
| 17 | 30 ± 0.20 | 1.25 | 28 ± 0.25 | 5.00 | 16 ± 0.23 | 5.00 | 11 ± 0.05 | 3.80 | 22 ± 0.20 | 10.00 | 25 ± 0.09 | 10.00 |
| 18 | 28 ± 0.17 | 2.50 | 26 ± 0.17 | 7.50 | 15 ± 0.12 | 7.50 | 13 ± 0.21 | 15.63 | 24 ± 0.27 | 3.13 | 23 ± 0.20 | 15.63 |
| Tetracycline | 25 ± 0.01 | 31.25 | 25 ± 0.04 | 62.50 | 23 ± 0.31 | 15.63 | 20 ± 0.10 | 62.50 | – | – | – | – |
| Ciprofloxacin | 29 ± 0.15 | 0.80 | 27 ± 0.23 | 0.78 | 27 ± 0.98 | 1.57 | 24 ± 0.47 | 3.13 | – | – | 22 ± 0.50 | 1.25 |
| Vancomycin | 21 ± 0.40 | 1.95 | 17 ± 0.11 | 1.57 | 24 ± 0.20 | 1.38 | 22 ± 0.85 | 2.50 | – | – | 14 ± 0.65 | 3.90 |
| Amphotericin B | – | – | – | – | – | – | – | – | 22± 0.11 | 15.63 | – | – |
Notes: NA indicates no activity. (-) indicates not tested. Each value represents the mean of three different experiments ± standard error. Tetracycline, ciprofloxacin and vancomycin were used as standards against the tested bacteria while Amphotericin B was used for fungi.