Table 2.

Effects of rosuvastatin (Ros) and atorvastatin (Ator) on body weight and lipid profile of rats at week 10

Animal group	Sham (II) (n = 8)		HCD group (III) (n = 8)		HCD + Ros (IV) (n = 8)		HCD + Ator (V) (n = 8)
	Before	After	Before	After	Before	After	Before	After
Weight (g)	251.62 ± 15.24	264.37 ± 18.01	284.50 ± 27.08a	314.38 ± 30.52	283.25 ± 13.22a	292.00 ± 12.44	290.00 ± 12.81a	294.38 ± 8.10
Cholesterol (mg/dl)	50.1 ± 4.97	52.37 ± 9.87	97.25 ± 33.93a	91.87 ± 19.96	98.50 ± 29.15a	46.00 ± 5.95c	94.50 ± 28.47a	54.25 ± 8.32c
Triglycerides (mg/dl)	58.25± 10.02	47.87 ± 26.01	50.25 ± 19.79	57.62 ± 11.34	50.75 ± 5.28	25.50 ± 5.07c	48.00 ± 11.10	27.00 ± 7.54c
HDL-C (mg/dl)	32.04 ± 3.43	34.47 ± 6.51	23.45 ± 4.47a	23.37 ± 6.75	22.97 ± 4.72a	34.25 ± 5.86b	24.20 ± 5.12a	33.00 ± 4.40b
LDL-C (mg/dl)	6.40 ± 3.33	8.32 ± 4.20	63.75 ± 31.99a	56.97 ± 16.34	65.37 ± 26.06a	6.67 ± 1.99c,d	60.67 ± 25.87a	18.35 ± 3.58c
VLDL-C (mg/dl)	11.65 ± 2.00	9.57 ± 5.20	10.05 ± 3.96	11.52 ± 2.27	10.15 ± 1.06	5.10 ± 1.01c	9.60 ± 2.22	5.40 ± 1.50c
AI	0.57 ± 0.14	0.53 ± 0.22	3.08 ± 0.83a	3.05 ± 0.87	3.53± 0.93a	0.37± 0.086c,d	2.89 ± 0.69a	0.73 ± 0.18c

Sham, rats fed with normal diet+water gavage; HCD, rats fed with hypercholesterolemic diet; HCD+Ros, rats fed with hypercholesterolemic diet+Ros (20 mg/kg); HCD+Ator, rats fed with hypercholesterolemic diet+Ator (20 mg/kg). Values are expressed as the means±SD

Ator, atorvastatin; Ros, rosuvastatin; LDL-C, low density lipoprotein cholesterol; VLDL-C, very low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; AI, Atherogenic index

^a P<0.01 vs. sham; ^b P<0.05 vs. HCD; ^c P<0.01 vs. HCD; ^d P<0.01 vs. HCD+Ator