Table 4.
Effect of rosuvastatin (Ros) and atorvastatin (Ator) on the serum markers of oxidative stress in rats
| Animal group | Sham (II) (n=8) |
HCD (III) (n=8) |
HCD + ROS (IV) (n=8) |
HCD + ATOR (V) (n=8) |
||||
|---|---|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | Before | After | |
| MDA (ng/ml) | 2.20 ± 0.20 | 2.26 ± 0.16 | 5.80 ± 0.26a | 5.90 ± 0.15 | 5.79 ± 0.32a | 3.35 ± .24b,c | 5.77 ± 0.21a | 3.91 ± 0.20b |
| OX-LDL (µg/ml) | 1.95 ± 0.09 | 1.97 ± 0.13 | 2.32 ± 0.16a | 2.35 ± 0.26 | 2.31 ± 0.06a | 1.66 ± 0.07b,c | 2.30 ±0.11a | 1.94 ± 0.18b |
Sham, rats fed with normal diet+water gavage; HCD, rats fed with hypercholesterolemic diet; HCD+Ros, rats fed with hypercholesterolemic diet+Ros (20 mg/kg); HCD+Ator, rats fed with hypercholesterolemic diet+Ator (20 mg/kg). Values are expressed as the means±SD
MDA, malondialdehyde; OX-LDL, oxidized low density lipoprotein
a P<0.01 vs. sham; b P<0.01 vs. HCD; c P< 0.01 vs. HCD+Ator