Skip to main content
. Author manuscript; available in PMC: 2021 Mar 6.
Published in final edited form as: Science. 2020 Mar 6;367(6482):1131–1134. doi: 10.1126/science.aba0672

Fig. 1. Ripple oscillations reflect burst firing of cortical neurons.

Fig. 1.

(A) Intraoperative photograph showing the implanted MEA in the MTG (top) and after placement of a macro-iEEG grid over the MEA (bottom). (B) Locations of the MEAs in five participants. Colors represent each participant. One participant with a right hemisphere implant is not shown. (C) Example of a coupled ripple oscillation between the MTL and MTG detected in macro-iEEG (top) with simultaneous cortical ripples present in the micro-LFP (middle; instantaneous spike rate of each channel indicated by color of trace) and burst firing of cortical single units (bottom). All 151 units measured during this session are shown, and 82 of these units spiked during this cortical ripple event. Spikes are shown with width of 5 ms for visualization purposes. (D) Average population spike rate relative to onset of ripples in the macro-iEEG (left) and average single-channel spike rate relative to onset of ripples in the micro-LFP (right). t = 0 indicates start index of detected ripple oscillation. Error bars represent SEM across all participants. (E) A representative single-channel spike raster locked to the maximum trough of each ripple oscillation recorded in that channel (top), with average spike rate (middle) and LFP (bottom) across all ripple events. t = 0 indicates trough of detected ripple oscillation. (F) Phase preference of spikes with respect to ripple phase (80 to 120 Hz). Dotted line indicates uniform distribution that would be expected by chance given the number of histogram bins. Error bars represent SEM across all participants.