Figure 4.

Image plots of the coupling benefit associated with combining TAP (a) and GTAP (b) with pre-pandemic vaccination at a compliance rate of 70% as functions of delay period and the compliance rate with the specified reactive protocol within targeted groups. Coupled suppression refers to the illness suppression provided by combining reactive antiviral prophylaxis and pre-pandemic vaccination, while combined suppression refers to the sum of the suppression provided by each component strategy taken individually. The blank areas (marked n.a. in (b)) define regions where the combined suppression is greater than the attack rate expected when no intervention is used and the coupling benefit does not provide an intuitive interpretation. The red contours correspond to coupling benefit values of 0, where the suppression provided by the combined strategy is simply the sum of the suppression provided by each separate method.