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. Author manuscript; available in PMC: 2020 May 10.
Published in final edited form as: Trends Cancer. 2020 Mar 2;6(5):369–379. doi: 10.1016/j.trecan.2020.02.002

Figure 3. Decreased Rap1 Expression is Associated with KRas Mutation.

Figure 3.

(A) Shallow deletion of RAP1A and KRAS mutation co-occur in pancreatic and lung cancers. The distribution of KRAS somatic mutations and RAP1A copy number variations (CNV) in the Cancer Genome Atlas (TCGA) pancreatic and lung cancers obtained from cBioPortal. cBioPortal was queried over all completed tumors from the PanCancer Atlas datasets using the Onco Query Language (OQL), ‘RAP1A:HETLOSS; KRAS: G12, G13, K61.’ (B) Shallow deletion of RAP1A leads to decreased mRNA in pancreatic and lung cancers. The plots are generated by cBioPortal (www.cbioportal.org) [97,98]. Abbreviation: GISTIC, Genomic Identification of Significant Targets in Cancer.