| 1.1 Depression: meeting study criteria for depression at end treatment |
9 |
734 |
Risk Ratio (M‐H, Random, 95% CI) |
0.50 [0.37, 0.68] |
| 1.1.1 CGI (high score = more severe) |
1 |
137 |
Risk Ratio (M‐H, Random, 95% CI) |
0.62 [0.34, 1.15] |
| 1.1.2 Clinician interview/impression (no improvement) |
1 |
65 |
Risk Ratio (M‐H, Random, 95% CI) |
0.45 [0.26, 0.79] |
| 1.1.3 Meets DSM‐III‐R criteria |
3 |
148 |
Risk Ratio (M‐H, Random, 95% CI) |
0.62 [0.27, 1.42] |
| 1.1.4 Meets DSM‐IV criteria |
2 |
181 |
Risk Ratio (M‐H, Random, 95% CI) |
0.33 [0.15, 0.69] |
| 1.1.5 HADS (high score = more severe) |
1 |
111 |
Risk Ratio (M‐H, Random, 95% CI) |
0.74 [0.32, 1.70] |
| 1.1.6 HDRS (high score = more depressed) |
1 |
92 |
Risk Ratio (M‐H, Random, 95% CI) |
0.14 [0.02, 1.12] |
| 1.2 Scoring above cut‐off points for a depressive disorder at end of treatment |
0 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Totals not selected |
| 1.3 Depression: average change in scores between baseline and end of treatment |
5 |
211 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.05 [‐0.33, 0.23] |
| 1.3.1 HDRS (high score = more depressed) |
4 |
100 |
Std. Mean Difference (IV, Random, 95% CI) |
‐0.16 [‐0.58, 0.26] |
| 1.3.2 HADS (high score = more depressed) |
1 |
111 |
Std. Mean Difference (IV, Random, 95% CI) |
0.04 [‐0.34, 0.41] |
| 1.4 Depression: mean scores at end of treatment |
4 |
100 |
Mean Difference (IV, Random, 95% CI) |
0.59 [‐1.46, 2.63] |
| 1.4.1 HDRS (high score = more depressed) |
4 |
100 |
Mean Difference (IV, Random, 95% CI) |
0.59 [‐1.46, 2.63] |
| 1.5 Cognition: average change in scores between baseline and end of treatment |
3 |
159 |
Mean Difference (IV, Random, 95% CI) |
0.11 [‐1.02, 1.24] |
| 1.5.1 MMSE (low score = cognitive impairment) |
3 |
159 |
Mean Difference (IV, Random, 95% CI) |
0.11 [‐1.02, 1.24] |
| 1.6 Cognition: Mean scores at end of treatment |
2 |
48 |
Mean Difference (IV, Random, 95% CI) |
‐0.42 [‐2.60, 1.76] |
| 1.6.1 MMSE (low score = cognitive impairment) |
2 |
48 |
Mean Difference (IV, Random, 95% CI) |
‐0.42 [‐2.60, 1.76] |
| 1.7 Activities of daily living: average change in scores between baseline and end of treatment |
3 |
57 |
Mean Difference (IV, Random, 95% CI) |
1.18 [‐7.77, 10.14] |
| 1.7.1 Barthel Index (high score = more dependent) |
3 |
57 |
Mean Difference (IV, Random, 95% CI) |
1.18 [‐7.77, 10.14] |
| 1.8 Activities of daily living: mean scores at end of treatment |
3 |
116 |
Mean Difference (IV, Random, 95% CI) |
‐3.86 [‐9.48, 1.77] |
| 1.8.1 Barthel Index (high score = more dependent) |
2 |
52 |
Mean Difference (IV, Random, 95% CI) |
0.75 [‐12.97, 14.47] |
| 1.8.2 Activities of daily living Index (high score = more dependent) |
1 |
64 |
Mean Difference (IV, Random, 95% CI) |
‐5.18 [‐7.38, ‐2.98] |
| 1.9 Disability: average change in scores between baseline and end of treatment |
4 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.9.1 Hemispheric Stroke Scale Total Score (high score = more neurological deficit) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.9.2 Hemispheric Stroke Scale Motor Subscale (high score = more deficit) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.9.3 Hemispheric Stroke Scale Gait Subscale (high score = more deficit) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.9.4 Johns Hopkins Functioning Inventory (high score = less function) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.10 Disability: mean scores at end of treatment |
4 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.10.1 Hemispheric Stroke Scale total score (high score = more neurological deficit) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.10.2 Hemispheric Stroke Scale motor subscale (high score = more deficit) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.10.3 Hemispheric Stroke Scale gait subscale (high score = more deficit) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.10.4 Johns Hopkins Functioning Inventory (high score = less function) |
2 |
|
Mean Difference (IV, Random, 95% CI) |
Totals not selected |
| 1.11 Disability: moderate to severe disability at end of treatment |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
Not estimable |
| 1.11.1 Modified Rankin Scale |
1 |
111 |
Risk Ratio (M‐H, Fixed, 95% CI) |
Not estimable |
| 1.12 Adverse events: death |
9 |
496 |
Risk Ratio (M‐H, Random, 95% CI) |
1.25 [0.32, 4.91] |
| 1.12.1 At end of treatment |
9 |
496 |
Risk Ratio (M‐H, Random, 95% CI) |
1.25 [0.32, 4.91] |
| 1.13 Adverse events: all |
9 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 1.13.1 Central nervous system events (e.g. confusion, sedation, tremor) |
4 |
214 |
Risk Ratio (M‐H, Random, 95% CI) |
1.26 [0.51, 3.15] |
| 1.13.2 Gastrointestinal effects (e.g. constipation, diarrhoea) |
6 |
383 |
Risk Ratio (M‐H, Random, 95% CI) |
1.21 [0.67, 2.19] |
| 1.13.3 Recurrent stroke |
2 |
114 |
Risk Ratio (M‐H, Random, 95% CI) |
1.49 [0.25, 8.80] |
| 1.13.4 Vascular events ‐ not stroke (e.g. dizziness, palpitation) |
3 |
282 |
Risk Ratio (M‐H, Random, 95% CI) |
1.13 [0.84, 1.50] |
| 1.13.5 Psychiatric events (e.g. anxiety, increased depression) |
1 |
100 |
Risk Ratio (M‐H, Random, 95% CI) |
4.81 [0.24, 97.68] |
| 1.13.6 Other events ‐ not listed above (e.g. dysuria, eye discomfort) |
3 |
190 |
Risk Ratio (M‐H, Random, 95% CI) |
1.12 [0.44, 2.85] |
| 1.13.7 Protocol violation (e.g. refused treatment, withdrew consent) |
5 |
309 |
Risk Ratio (M‐H, Random, 95% CI) |
0.89 [0.62, 1.27] |
| 1.14 Adverse events: leaving the study early (including death) |
12 |
836 |
Risk Ratio (M‐H, Random, 95% CI) |
1.03 [0.84, 1.26] |
| 1.14.1 All dropouts and withdrawals |
12 |
836 |
Risk Ratio (M‐H, Random, 95% CI) |
1.03 [0.84, 1.26] |
