TABLE 2.
Univariable Analysis of Factors Associated With the Development of Breast Cancer Among Women with LCIS
| Characteristic | n | HR | 95% CI | p-value |
|---|---|---|---|---|
| Age at LCIS diagnosis | 1222 | 0.6 | ||
| < 50 | Ref. | |||
| ≥ 50 | 1.08 | 0.81-1.45 | ||
| Menopausal status | 1190 | 0.9 | ||
| Pre/perimenopausal | Ref. | |||
| Postmenopausal | 0.98 | 0.72-1.33 | ||
| Family History | ||||
| ≥ 1 FDR with breast cancer | 1198 | 1.33 | 0.97-1.81 | 0.077 |
| ≥ 2 SDRs with breast cancer | 1198 | 0.83 | 0.50-1.39 | 0.5 |
| Any (≥ 1 FDR with breast cancer or ≥ 2 SDRs with breast cancer) | 1198 | 1.24 | 0.92-1.68 | 0.2 |
| BIRADS | 1222 | < 0.001 | ||
| A/B | Ref. | |||
| C/D | 2.13 | 1.39-3.26 | ||
| BMI categories | 1222 | > 0.9 | ||
| Normal weight (BMI < 25) | Ref. | |||
| Overweight (BMI ≥ 25, < 30) | 1.00 | 0.71-1.41 | ||
| Obese (BMI ≥ 30, < 35) | 1.00 | 0.61-1.66 | ||
| Very obese (BMI ≥ 35) | 1.25 | 0.67-2.34 | ||
| MRI screening | 1222 | 0.88 | 0.66-1.19 | 0.4 |
| Chemoprevention | 1222 | 0.49 | 0.29-0.83 | 0.007 |
HR hazard ratio, CI confidence interval, LCIS lobular carcinoma in situ, BIRADS Breast Imaging Reporting and Data System, FDR first-degree relative, SDR second-degree relative, BMI body mass index