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. 2020 May 11;130:106680. doi: 10.1016/j.vph.2020.106680

Table 4.

Summary of studies which assessed association between miRNAs and ACE proteins.

miRNA Disease Samples Function Reference
let-7b Hypoxic pulmonary hypertension (HPH) let-7b−/− rat HIF-1α-dependent hypoxia stimulated let-7b inhibited ACE2 expression via the HIF-1α-let-7b-ACE2 axis and contributed to the HPH [86]
miR-421 Cardiovascular disease (CVD) Primary cardiac myofibroblasts miR-421 down-regulates ACE2 expression. [14]
Chronic Kidney Disease (CKD) Circulating leukocytes A significant, inverse correlation between circulating miR-421serum level and the ACE2 expression in leucocytic was shown. Also, ACE2 upregulation following Anti-miR-421 treatment was reported [87]
miR-1246 acute lung injury (ALI) LPS-exposed pulmonary microvascular endothelial cells (PMVECs) miR-1246 meditates LPS-induced pulmonary endothelial cell apoptosis in vitro and ALI in mouse models, by targeting ACE2. [88]
miR-200c-3p Acute respiratory distress syndrome (ARDS) HEK293T cells Avian influenza virus H5N1 induced the miR-200c-3p upregulation via an NF-κB dependent manner to reduce ACE2 levels and cause lung injury [13]
miR-483-3p Vascular diseases human embryonic kidney (HEK-293) miR-483-3p target 3′-UTRs of AGT, ACE-1, ACE-2 and AT2R [89]
miR-4262 acute lung injury (ALI) bleomycin-induced ALI mouse ACE2-induced suppression of miR-4262, which lead to Bcl-2 protein upregulation, decreased the ALI severity by inhibiting the apoptosis of PECs [90]