Table 2. Sequence context of C:G>T:A mutations observed in PD1487a and PD1489a compared with the expected sequence context.

Sequence context of mutation	ACA	CCA	GCA	TCA	ACC	CCC	GCC	TCC	ACG	CCG	GCG	TCG	ACT	CCT	GCT	TCT
Percent observed mutations (%)	0	8	5	6	11	22	3	14	0	2	0	2	9	8	3	7
Percent expected mutations (%)	7	10	7	8	6	7	7	8	2	4	3	3	5	8	8	8

NOTE: The expected sequence context was derived from the entire set of trinucleotides centered around all cytosines in the coding sequences of the protein kinases. Underlined C is the mutated base.