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. 2019 Sep 28;69(6):1092–1103. doi: 10.1136/gutjnl-2019-319126

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Methylation of key negative regulator genes. (A) Methylation (mean beta value) of AXIN2 and NKD1 showing differential methylation of Wnt NR genes between LD and LI tumours. (B) Methylation (mean beta value) of AXIN2 and NKD1 shows no significant difference between CpG island methylator phenotype (CIMP) positive (blue), and negative (red) LD and LI tumours. (C) Significant anticorrelation between AXIN2 and NKD1 normalised gene expression (log-counts per million/CPM) and gene methylation (mean beta value). All data from discovery cohort A (TCGA).