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. Author manuscript; available in PMC: 2020 May 11.
Published in final edited form as: Nature. 2006 Dec 14;444(7121):894–898. doi: 10.1038/nature05413

Fig. 1. The families used to map the locus for channelopathy-associated insensitivity to pain.

Fig. 1

Autozygosity mapping in families 1 and 2 on the left of the diagram enabled the identification of a shared 20 cM homozygous region on chromosome 2q24 (there were no other significant homozygous regions detected). The two-point LOD score was 3.2 at θ = 5 0, for AC064843GT21 and AC092641TG18, but greater for more informative markers, see Supplementary Table 1. Family 3, on the right of the diagram, was used to refine this region to an 11.7-Mb shared homozygous region flanked by the heterozygous markers D2S1353 and AC012594TG25 and defined by the homozygous markers AC064843GT21 and AC092641TG18. Affected individuals are indicated with filled symbols.