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Treatment algorithm for patients with advanced surgically untreatable liver-dominant (unresectable) metastatic colorectal cancer (mCRC). ALPPS, associating liver partition and portal vein ligation for staged hepatectomy; ESMO, European Society for Medical Oncology; FLR, future liver remnant; HAI, hepatic artery infusion; PVE, portal vein embolization; RCTs, randomized controlled trials; SIRT, selective internal radiation therapy.
