Table 4. Unadjusted perioperative outcomes for the entire cohort and for the subset of patients with large tumors.
| Perioperative outcomes | Entire cohort | Patients with tumor size ≥8 cm | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total (n=1,849) | No induction therapy (n=1,683) | Induction therapy (n=166) | P | Total (n=582) | No induction therapy (n=480) | Induction therapy (n=102) | P | |||
| Days to definitive surgery, median [IQR] | 1 [0, 41.8] | 0 [0, 30] | 137 [111, 174] | <0.001 | 20 [0, 63] | 11 [0, 34] | 138 [116.2, 174.8] | <0.001 | ||
| Margin status, n (%) | 0.439 | 0.539 | ||||||||
| R0 | 1,251 (67.7) | 1,138 (67.6) | 113 (68.1) | 377 (64.8) | 305 (63.5) | 72 (70.6) | ||||
| R1 | 251 (13.6) | 227 (13.5) | 24 (14.4) | 82 (14.1) | 68 (14.2) | 14 (13.7) | ||||
| R2 | 31 (1.7) | 26 (1.5) | 5 (3.0) | 11 (1.9) | 8 (1.7) | 3 (2.9) | ||||
| Positive NOS | 163 (8.8) | 151 (9.0) | 12 (7.2) | 56 (9.6) | 49 (10.2) | 7 (6.9) | ||||
| Unknown | 153 (8.3) | 141 (8.4) | 12 (7.2) | 56 (9.6) | 50 (10.4) | 6 (5.9) | ||||
| Any positive margin, n (%) | 445 (24.1) | 404 (24.0) | 41 (24.7) | 0.986 | 149 (25.6) | 125 (26.0) | 24 (23.5) | 0.500 | ||
| Adjuvant chemotherapy, n (%) | 118 (6.4) | 104 (6.2) | 14 (8.4) | 0.333 | 45 (7.7) | 42 (8.8) | 3 (2.9) | 0.063 | ||
| Adjuvant radiation, n (%) | 790 (42.7) | 734 (43.6) | 56 (33.7) | 0.018 | 267 (45.9) | 233 (48.5) | 34 (33.3) | 0.007 | ||
| Hospital length of stay, median [IQR] | 4 [3, 6] | 4 [3, 5] | 5 [3, 7] | <0.001 | 4 [3, 7] | 4 [3, 6] | 5 [4, 8] | 0.002 | ||
| Unplanned readmission, n (%) | 57 (3.1) | 54 (3.2) | 3 (1.8) | 0.265 | 13 (2.2) | 13 (2.7) | 0 (0.0) | 0.272 | ||
| 30-day mortality, n (%) | 15 (0.8) | 12 (0.7) | 3 (1.8) | 0.146 | 6 (1.0) | 4 (0.8) | 2 (2.0) | 0.287 | ||
| 90-day mortality, n (%) | 27 (1.5) | 22 (1.2) | 5 (3.0) | 0.090 | 8 (1.4) | 4 (0.8) | 4 (3.9) | 0.036 | ||