Table 1.

Standard protocol items: recommendations for interventional trials (SPIRIT).

Time point (week)	Study period
	Enrolment	Baseline	Post-allocation												Follow up
		W0	W1	W2	W3	W4	W5	W6	W7	W8	W9	W10	W11	W12	W13
Enrolment
Eligibility screen	X
Informed consent	X
Randomization	X
Allocation	X
Interventions
High BJ dose
Medium BJ dose
Low BJ dose
Placebo (control)
Assessments
Demographic data	X
Anthropometric measurement		X						X							X
Physical activity questionnaire		X													X
Blood pressure		X													X
Endothelial function test		X													X
Pulmonary function test		X													X
Cognitive function test		X													X
Cerebral blood flow test		X													X
Dietary intake				X		X		X		X		X		X
Blood samples		X													X
Saliva samples		X				X				X					X
Urine samples		X				X				X					X
Salivary Strips		X				X				X					X
Participant feedback															X

W = week of the study.