Figure 4.

A theoretical calculation of how many IL‐6 molecules are bound to various target cells at different concentrations of free plasma IL‐6. The red circle marks the range of physiological plasma IL‐6 concentrations and the concomitant number of IL‐6 molecules bound per cell. Hepatocytes and MNC are likely IL‐6 stimulated whereas circulating PNG is unstimulated under normal physiological conditions. Circulating PNG is activated only when measurable plasma levels of free IL‐6 rise above 50 pg/mL. IL‐6, interleukin‐6; MNC, mononuclear cell; PNG, polymorph nuclear granulocyte