Table 2.
B max and Kd for IL‐6 binding factors in the blood
| IL‐6 binding factors | Kd, pM | Receptor number per cell | B max in 3l of plasma, pM |
|---|---|---|---|
| Mononuclear cells | 15 | 284 | 2.83 |
| Granulocytes | 15 | 48 | 0.77 |
| Hepatocytes | 15 | 600‐9000 | 69‐1000 |
| Spleen cells | 15 | 284 | 4.1 |
| sIL‐6R | 5000‐50 000 | 650‐2000 a |
Note: Mononuclear cells, (see Table 1a), blood concentration ≈ 3 × 109 per liter blood ≈ 6 × 109 per liter plasma, 21 ; granulocytes, (see Table 1b), blood concentration ≈ 5 × 109 per liter blood ≈ 10 × 109 per liter plasma. 21 Hepatocytes, number in the liver: 139 × 109 per gram liver, liver mass ≈ 1.500 g. 21 , 22 , 23 Spleen cells, number of mononuclear cells 1.3 × 108 per gram spleen, spleen mass 200 g. 21 sIL‐6R, values of Kd and B max from the literature. 4 , 7 , 20
Abbreviations: IL‐6, interleukin‐6; sIL‐6R, soluble IL‐6 receptor.
a
Molecular weight set to 50 kDa. 2000 pM ≈ 100 ng/mL.