Table 3.
The binding of IL‐6 in blood in relation to different concentrations of free, measurable plasma IL‐6
| F, pM | B, pM/number of IL‐6 molecules bound per cell | ||||
|---|---|---|---|---|---|
| MNC | Granulocytes | Hepatocytes | Spleen | sIL‐6R | |
| 0.02 (0.5 pg/mL a ) | 0.004/0.38 | 0.001/0.064 | 0.09/0.80 | 0.005/0.38 | 0.003 |
| 0.08 (2 pg/mL) | 0.015/1.51 | 0.004/0.25 | 0.37/3.18 | 0.022/1.51 | 0.01 |
| 0.20 (5 pg/mL) | 0.037/3.74 | 0.010/0.63 | 0.91/7.89 | 0.054/3.74 | 0.03 |
| 0.40 (10 pg/mL) | 0.074/7.38 | 0.020/1.25 | 1.79/15.58 | 0.106/7.38 | 0.05 |
| 1.00 (25 pg/mL) | 0.177/17.75 | 0.048/3.00 | 4.31/37.50 | 0.256/17.75 | 0.13 |
| 25.00 (625 pg/mL) | 1.769/177.50 | 0.481/30.00 | 43.13/375.00 | 2.563/177.50 | 3.23 |
Abbreviations: IL‐6, interleukin‐6; MNC, mononuclear cell; sIL‐6R, soluble IL‐6 receptor.
a
The molecular weight of native IL‐6 was set to 25 000 grams per mole.