Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 25;16(3):699–706. doi: 10.5114/aoms.2020.94659

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2019 Termedia & Banach

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

PMC Copyright notice

Bielschowsky staining in cerebral cortex and CA₁ region of hippocampus. Cerebral cortex in normal control group (A) showed normal neuronal cell body (arrow) and vessels (arrowhead). CA₁ of hippocampus in normal control group (B) showed normal neuronal cell (arrowhead) population. Sham-operated group (C) revealed normal neuron (arrowhead) in the cortex. Normal rats administered β-asarone at doses of 12.5 (D), 25 (E), and 50 (F) mg/kg revealed a normal neuronal cell body (arrowhead). Alzheimer’s control group revealed neuritic plaques (arrow) in cerebral cortex (G) and in CA₁ (H). Also, loss of neuronal cell population (arrow) and neurofibrillary tangles (arrowhead) was seen. β-asarone at dose of 12.5 mg/kg (I) led to moderate neurofibrillary tangles (arrowhead) and neuronal necrosis (arrow) in Alzheimeric rats. Administration of β-asarone at doses of 25 (J), 50 (L) mg/kg revealed few neurofibrillary tangles (arrow) in cortex, improved neuronal population (arrowhead) and decreased neuronal necrosis (arrow) in CA₁ (K, M)

Bielschowsky staining in cerebral cortex and CA₁ region of hippocampus. Cerebral cortex in normal control group (A) showed normal neuronal cell body (arrow) and vessels (arrowhead). CA₁ of hippocampus in normal control group (B) showed normal neuronal cell (arrowhead) population. Sham-operated group (C) revealed normal neuron (arrowhead) in the cortex. Normal rats administered β-asarone at doses of 12.5 (D), 25 (E), and 50 (F) mg/kg revealed a normal neuronal cell body (arrowhead). Alzheimer’s control group revealed neuritic plaques (arrow) in cerebral cortex (G) and in CA₁ (H). Also, loss of neuronal cell population (arrow) and neurofibrillary tangles (arrowhead) was seen. β-asarone at dose of 12.5 mg/kg (I) led to moderate neurofibrillary tangles (arrowhead) and neuronal necrosis (arrow) in Alzheimeric rats. Administration of β-asarone at doses of 25 (J), 50 (L) mg/kg revealed few neurofibrillary tangles (arrow) in cortex, improved neuronal population (arrowhead) and decreased neuronal necrosis (arrow) in CA₁ (K, M)