Date	Event	Description
28 January 2015	New search has been performed	A search of the Cystic Fibrosis and Genetic Disorders Group's Inborn Errors of Metabolism Register identified 51 references. A total of 43 records were excluded after preliminary screening of titles or abstracts (or both). Of the remaining eight potentially eligible trials, six were evaluated and then added to the 'Excluded studies' section, a further trial is already listed in the 'Studies awaiting classification' section (Giovannini 2006) and the remaining trial has been added to 'Studies awaiting classification' (Lange 2004).
28 January 2015	New citation required but conclusions have not changed	Minor changes have been made throughout the text for this update.