Date	Event	Description
11 March 2011	New search has been performed	A search of the Group's Inborn Errors of Metabolism Trials Register identified eleven potentially relevant references, although only one was eligible for inclusion in the review. This was an additional reference to an already excluded study (MacDonald 2006c).
13 May 2009	Amended	No changes ‐ republished to fix technical problem.
18 July 2008	New citation required but conclusions have not changed	New review team in place.
18 July 2008	New search has been performed	Two new trials have been included in the review (MacDonald 2006b; Schindeler 2007). Note: MacDonald 2006b was previously listed in 'Ongoing studies'. Fourteen new trials have been added to the 'Excluded studies' section of this review (Agostini 2006; Baumgartner 2004; Cleary 2003; Cleary 2006; Kalkanoglu 2005; Koletzko 2007; Levy 2007; MacDonald 2003a; MacDonald 2005; MacDonald 2006c; Marsden 2005; Matalon 2006; Matalon 2007; Rose 2005). Note: Cleary 2003 was previously listed in 'Studies awaiting assessment'. One new study has been added to 'Studies awaiting assessment' (Giovannini 2006).
10 July 2008	Amended	Converted to new review format.
1 September 2006	New search has been performed	Five new trials have been identified by the latest search. Four of these are now listed in 'Excluded studies' (Baumgartner 2004; Kalkanoglu 2005; MacDonald 2005; Rose 2005) and one in 'Studies awaiting assessment' (Marsden 2005).