| Study | Reason for exclusion |
|---|---|
| Acosta 1994 | Not a CCT or RCT. Ascertained by communication with current head of metabolic products who contacted the author (her predecessor in post). Infants fed Analog XP were studied first, and Phenex study began after this. |
| Agostoni 2006 | Intervention not eligible for inclusion. |
| Ahring 2010 | Intervention not eligible for inclusion. |
| Ahring 2012 | Intervention not eligible for inclusion. |
| Baumgartner 2004 | Intervention not eligible for inclusion. |
| Cleary 2003 | Participants and intervention not eligible for inclusion. |
| Cleary 2006 | Intervention not eligible for inclusion. |
| Clemens 1991 | Not a CCT or RCT. |
| Gokmen‐Ozel 2011 | Intervention not eligible for inclusion. |
| Kalkanoglu 2005 | Group of participants not eligible for inclusion. |
| Koletzko 2007 | Intervention not eligible for inclusion. |
| Levy 2007 | Intervention not eligible for inclusion. |
| MacDonald 2003a | Intervention not eligible for inclusion. The trial did not set out to compare two different doses of protein substitute intake, but examined a group of 20 participants with PKU and studied the effects of giving participants at least 40% of their daily protein substitute requirements as tablets for at least 12 weeks. There was better compliance with protein substitute as tablets, therefore, in this trial, different intakes of protein substitute were only measured as outcomes. |
| MacDonald 2005 | Intervention not eligible for inclusion. |
| MacDonald 2006a | Intervention not eligible for inclusion. |
| MacDonald 2006c | Participants, intervention, and outcomes not eligible for inclusion. |
| MacDonald 2008 | Intervention not eligible for inclusion. |
| Marsden 2005 | Participants and intervention not eligible for inclusion. |
| Matalon 2006 | Intervention not eligible for inclusion. |
| Matalon 2007 | Intervention not eligible for inclusion. |
| Rose 2005 | Intervention not eligible for inclusion. |
| SHS 2001 | Not a CCT or RCT (ascertained by communication with co‐ordinator of original study at SHS). |
| Stroem 2011 | Intervention not eligible for inclusion. |
| ten Hoedt 2011 | Intervention not eligible for inclusion. |
CCT: controlled clinical trial PKU: phenylketonuria RCT: randomized controlled trial