Table 2.
Hazard Ratios for Incident CHD per 1 SD Increase in PRS
| HR (95% CI)a | p Valuea | ModelBasec-indexb | ModelPRSc-indexc | pinteractiond | |
|---|---|---|---|---|---|
| EA | |||||
| PRSTikkanen | 1.18 (1.13–1.23) | 6.54 × 10−14 | 0.690 | 0.697 | ref |
| PRSTada | 1.20 (1.15–1.25) | <2 × 10−16 | 0.690 | 0.698 | ref |
| PRSLDPred | 1.50 (1.43–1.56) | <2 × 10−16 | 0.690 | 0.719 | ref |
| PRSmetaGRS | 1.53 (1.46–1.60) | <2 × 10−16 | 0.690 | 0.719 | ref |
| AA | |||||
| PRSTikkanen | 1.11 (0.99–1.24) | 0.07 | 0.649 | 0.652 | 0.39 |
| PRSTada | 1.05 (0.94–1.17) | 0.41 | 0.649 | 0.649 | 0.02 |
| PRSLDPred | 1.19 (1.07–1.33) | 2.2 × 10−3 | 0.649 | 0.656 | 1.6 × 10−4 |
| PRSmetaGRS | 1.27 (1.13–1.43) | 4.1 × 10−5 | 0.649 | 0.663 | 2.9 × 10−3 |
| HE | |||||
| PRSTikkanen | 1.14 (0.94–1.37) | 0.19 | 0.654 | 0.655 | 0.77 |
| PRSTada | 1.13 (0.93–1.36) | 0.22 | 0.654 | 0.654 | 0.53 |
| PRSLDPred | 1.16 (0.96–1.41) | 0.13 | 0.654 | 0.659 | 0.02 |
| PRSmetaGRS | 1.53 (1.23–1.90) | 1.1 × 10−4 | 0.654 | 0.683 | 0.77 |
a
Age-as-time-scale Cox regression models separate for each racial and ethnic group adjusted for sex, eMERGE site, and first five ancestry-specific principal components.
b
c-indices for base models without PRSs across racial and ethnic groups: age-as-time-scale Cox model with sex, eMERGE site, and first five ancestry-specific principal components.
c
c-indices for base model + PRSs for each racial and ethnic group.
d
Age-as-time-scale Cox regression models on the joint cohort adjusted for sex, eMERGE site, design matrix of first five ancestry-specific principal components, racial and ethnic group, and an interaction term with PRSs. ref, referent.