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. 2020 May 7;106(5):707–716. doi: 10.1016/j.ajhg.2020.04.002

Table 3.

Odds Ratios for (All) CHD per 1 Standard Deviation Increase in PRS

OR (95% CI)a p valuea ModelBasec-indexb ModelPRSc-indexc pinteractiond
EA
PRSTikkanen 1.24 (1.21–1.28) <2 × 10−16 0.742 0.748 ref
PRSTada 1.28 (1.25–1.32) <2 × 10−16 0.742 0.750 ref
PRSLDPred 1.66 (1.62–1.71) <2 × 10−16 0.742 0.770 ref
PRSmetaGRS 1.73 (1.68–1.78) <2 × 10−16 0.742 0.772 ref
AA
PRSTikkanen 1.07 (0.99–1.16) 0.08 0.762 0.763 3.7 × 10−4
PRSTada 1.05 (0.98–1.14) 0.19 0.762 0.763 1.7 × 10−6
PRSLDPred 1.30 (1.21–1.41) 1.6 × 10−11 0.762 0.771 5.4 × 10−9
PRSmetaGRS 1.40 (1.30–1.52) <2 × 10−16 0.762 0.775 3.6 × 10−6
HE
PRSTikkanen 1.27 (1.12–1.42) 1.0 × 10−4 0.765 0.771 0.69
PRSTada 1.20 (1.06–1.35) 3.4 × 10−3 0.765 0.769 0.28
PRSLDPred 1.42 (1.25–1.61) 4.9 × 10−8 0.765 0.776 0.03
PRSmetaGRS 1.93 (1.67–2.22) <2 × 10−16 0.765 0.794 0.09
a

Multivariable logistic-regression models, separate for each racial and ethnic group, adjusted for age at first EHR record, duration of EHR, sex, eMERGE site, and first five ancestry-specific principal components.

b

c-indices for base models without PRSs across racial and ethnic groups: multivariable logistic-regression model with age at first EHR record, duration of EHR, sex, eMERGE site, and first five ancestry-specific principal components.

c

c-indices for base model + PRSs for each racial and ethnic group.

d

Multivariable logistic regression models on the joint cohort adjusted for age at first EHR record, duration of EHR, sex, eMERGE site, design matrix of first five ancestry-specific principal components, racial and ethnic group, and an interaction term with PRSs. ref, referent.