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. 2020 Apr 9;106(5):611–622. doi: 10.1016/j.ajhg.2020.03.007

Figure 1.

Figure 1

UK Biobank Phenotype Counts and Asthma Genetic Associations

(A and B) Screenshot of UK Biobank questionnaire where participants can (A) indicate that they have been diagnosed with specific cancers or other illnesses and (B) specify at what age they were diagnosed.

(C and D) Number of cases for each of 41 medical phenotypes where cases are defined using hospital records (blue), questionnaire responses (orange), or both combined (gray).

(E and F) Manhattan plots for asthma genome-wide association studies (GWAS) with cases defined by (E) hospital records or (F) questionnaire responses. Loss-of-function and missense variants with p < 5 × 10-8 are colored blue and green, respectively. Grey dots indicate all other variants.