Table 3.
The most promising MHC class II-related peptides in the envelope protein-based vaccine of COVID-19 along with the predicted coverage of the world, China, Europe, and East Asia.
| Peptide sequence | Alleles | World coverage | Coverage/10 peptides |
|---|---|---|---|
| KPSFYVYSRVKNLNS | HLA-DPA1∗01:03, HLA-DPB1∗02:01, HLA-DPB1∗03:01, HLA-DPB1∗04:01, HLA-DPA1∗02:01, HLA-DPB1∗05:01, HLA-DPA1∗03:01, HLA-DPB1∗04:02, HLA-DPB1∗06:01, HLA-DPB1∗14:01, HLA-DPB1∗01:01, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQA1∗06:01, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DQA1∗02:01, HLA-DRB1∗01:01, HLA-DRB1∗07:01, HLA-DRB1∗08:01, HLA-DRB1∗09:01, HLA-DRB1∗11:01, HLA-DRB4∗01:03, HLA-DRB1∗04:01, HLA-DRB1∗10:01, HLA-DRB1∗04:05, HLA-DRB1∗13:01, HLA-DRB1∗08:02, HLA-DRB1∗16:02, HLA-DRB1∗15:01, HLA-DRB3∗03:01, HLA-DRB5∗01:01, HLA-DRB3∗02:02, HLA-DRB1∗04:04, HLA-DRB1∗13:02 | 99.93% | World: 99.99% |
| VKPSFYVYSRVKNLN | HLA-DPA1∗01:03, HLA-DPB1∗02:01, HLA-DPB1∗04:01, HLA-DPB1∗03:01, HLA-DPA1∗02:01, HLA-DPB1∗05:01, HLA-DPA1∗03:01, HLA-DPB1∗04:02, HLA-DPB1∗06:01, HLA-DPB1∗01:01, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQA1∗06:01, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DQA1∗02:01, HLA-DRB1∗07:01, HLA-DRB1∗08:01, HLA-DRB1∗01:01, HLA-DRB1∗09:01, HLA-DRB1∗11:01, HLA-DRB4∗01:03, HLA-DRB1∗15:01, HLA-DRB1∗13:01, HLA-DRB3∗03:01, HLA-DRB1∗10:01, HLA-DRB1∗16:02, HLA-DRB1∗08:02, HLA-DRB1∗04:05, HLA-DRB5∗01:01, HLA-DRB1∗13:02, HLA-DRB3∗02:02, HLA-DRB1∗04:01, HLA-DRB1∗04:04 | 99.92% | China: 99.96% |
| LVKPSFYVYSRVKNL | HLA-DPA1∗01:03, HLA-DPB1∗02:01, HLA-DPB1∗04:01, HLA-DPA1∗02:01, HLA-DPB1∗05:01, HLA-DPB1∗06:01, HLA-DPA1∗03:01, HLA-DPB1∗04:02, HLA-DPA1∗02:01, HLA-DPB1∗01:01, HLA-DQA1∗06:01, HLA-DQB1∗04:02, HLA-DQA1∗05:01, HLA-DQA1∗02:01, HLA-DQA1∗01:04, HLA-DQB1∗05:03, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DRB1∗07:01, HLA-DRB1∗08:01, HLA-DRB1∗09:01, HLA-DRB1∗11:01, HLA-DRB4∗01:03, HLA-DRB3∗03:01, HLA-DRB1∗01:01, HLA-DRB1∗15:01, HLA-DRB1∗16:02, HLA-DRB1∗13:01, HLA-DRB1∗10:01, HLA-DRB1∗08:02, HLA-DRB5∗01:01, HLA-DRB1∗13:02, HLA-DRB1∗04:05, HLA-DRB3∗02:02, HLA-DRB1∗04:01 | 99.90% | Europe: 100.0% |
| PSFYVYSRVKNLNSS | HLA-DPA1∗01:03, HLA-DPB1∗02:01, HLA-DPB1∗03:01, HLA-DPB1∗04:01, HLA-DPA1∗03:01, HLA-DPB1∗04:02, HLA-DPA1∗02:01, HLA-DPB1∗05:01, HLA-DPB1∗06:01, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DQA1∗06:01, HLA-DRB1∗01:01, HLA-DRB1∗08:01, HLA-DRB1∗04:01, HLA-DRB1∗11:01, HLA-DRB1∗09:01, HLA-DRB1∗07:01, HLA-DRB4∗01:03, HLA-DRB1∗04:05, HLA-DRB1∗10:01, HLA-DRB1∗13:01, HLA-DRB1∗08:02, HLA-DRB1∗16:02, HLA-DRB1∗15:01, HLA-DRB3∗03:01, HLA-DRB3∗02:02, HLA-DRB1∗04:04, HLA-DRB5∗01:01, HLA-DRB1∗13:02 | 99.86% | East Asia:99.91% |
| NIVNVSLVKPSFYVY | HLA-DPA1∗01:03, HLA-DPB1∗02:01, HLA-DPB1∗04:01, HLA-DPB1∗06:01, HLA-DPA1∗02:01, HLA-DPB1∗01:01, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQA1∗02:01, HLA-DQB1∗03:01, HLA-DQB1∗03:03, HLA-DQB1∗03:03, HLA-DQB1∗04:02, HLA-DRB1∗12:01, HLA-DRB1∗01:01, HLA-DRB5∗01:01, HLA-DRB3∗03:01, HLA-DRB1∗13:01, HLA-DRB1∗07:01, HLA-DRB1∗15:01, HLA-DRB4∗01:03, HLA-DRB1∗04:04, HLA-DRB1∗08:02, HLA-DRB1∗09:01, HLA-DRB1∗13:02, HLA-DRB1∗11:01, HLA-DRB1∗04:05, HLA-DRB1∗10:01 | 99.77% | |
| LLVTLAILTALRLCA | HLA-DPA1∗01:03, HLA-DPB1∗02:01, HLA-DPB1∗06:01, HLA-DPA1∗03:01, HLA-DPB1∗04:02, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DQA1∗02:01, HLA-DQB1∗03:01, HLA-DQB1∗03:03, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQA1∗06:01, HLA-DQA1∗01:03, HLA-DQB1∗06:03, HLA-DRB4∗01:03, HLA-DRB1∗01:01, HLA-DRB1∗13:01, HLA-DRB1∗04:04, HLA-DRB5∗01:01, HLA-DRB3∗03:01, HLA-DRB1∗10:01, HLA-DRB1∗15:01, HLA-DRB1∗07:01, HLA-DRB1∗11:01, HLA-DRB1∗08:01, HLA-DRB1∗12:01, HLA-DRB1∗03:01, HLA-DRB4∗01:01, HLA-DRB1∗16:02, HLA-DRB1∗08:02 | 99.72% | |
| SFYVYSRVKNLNSSR | HLA-DPA1∗01:03, HLA-DPB1∗03:01, HLA-DPB1∗02:01, HLA-DPA1∗03:01, HLA-DPB1∗04:02, HLA-DPA1∗02:01, HLA-DPB1∗05:01, HLA-DPB1∗06:01, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DRB1∗04:01, HLA-DRB1∗01:01, HLA-DRB1∗11:01, HLA-DRB1∗08:01, HLA-DRB1∗07:01, HLA-DRB1∗09:01, HLA-DRB4∗01:03, HLA-DRB1∗10:01, HLA-DRB1∗13:01, HLA-DRB1∗04:05, HLA-DRB1∗08:02, HLA-DRB1∗16:02, HLA-DRB3∗02:02, HLA-DRB3∗03:01, HLA-DRB1∗04:04, HLA-DRB1∗15:01, HLA-DRB5∗01:01, HLA-DRB1∗13:02 | 99.72% | |
| LVTLAILTALRLCAY | HLA-DPA1∗01:03, HLA-DPB1∗02:01, HLA-DPB1∗06:01, HLA-DPA1∗03:01, HLA-DPB1∗04:02, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DQA1∗02:01, HLA-DQB1∗03:01, HLA-DQB1∗03:03, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQB1∗06:02, HLA-DQA1∗02:01, HLA-DQA1∗06:01, HLA-DRB4∗01:03, HLA-DRB1∗01:01, HLA-DRB1∗13:01, HLA-DRB1∗04:04, HLA-DRB1∗12:01, HLA-DRB1∗10:01, HLA-DRB5∗01:01, HLA-DRB1∗15:01, HLA-DRB1∗11:01, HLA-DRB3∗03:01, HLA-DRB1∗03:01, HLA-DRB1∗08:01, HLA-DRB1∗07:01, HLA-DRB4∗01:01, HLA-DRB1∗16:02, HLA-DRB1∗04:02, HLA-DRB1∗08:02 | 99.69% | |
| VTLAILTALRLCAYC | HLA-DPA1∗01:03, HLA-DPB1∗06:01, HLA-DPA1∗03:01, HLA-DPB1∗04:02, HLA-DQA1∗02:01, HLA-DQB1∗03:01, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DQB1∗06:02, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQB1∗03:03, HLA-DQA1∗06:01, HLA-DQB1∗04:02, HLA-DRB1∗01:01, HLA-DRB4∗01:03, HLA-DRB1∗13:01, HLA-DRB1∗04:04, HLA-DRB1∗12:01, HLA-DRB1∗10:01, HLA-DRB5∗01:01, HLA-DRB1∗15:01, HLA-DRB1∗11:01, HLA-DRB1∗03:01, HLA-DRB3∗03:01, HLA-DRB1∗08:01, HLA-DRB1∗07:01, HLA-DRB4∗01:01, HLA-DRB1∗04:02 | 99.56% | |
| CNIVNVSLVKPSFYV | HLA-DPA1∗01:03, HLA-DPB1∗06:01, HLA-DPB1∗04:02, HLA-DQA1∗01:02, HLA-DQB1∗05:01, HLA-DQA1∗05:01, HLA-DQB1∗04:02, HLA-DQA1∗02:01, HLA-DQB1∗03:01, HLA-DQB1∗03:03, HLA-DQA1∗01:03, HLA-DQB1∗06:03, HLA-DRB3∗03:01, HLA-DRB1∗12:01, HLA-DRB5∗01:01, HLA-DRB1∗01:01, HLA-DRB1∗07:01, HLA-DRB4∗01:03, HLA-DRB1∗13:01, HLA-DRB1∗15:01, HLA-DRB1∗08:02, HLA-DRB1∗04:04, HLA-DRB1∗09:01, HLA-DRB1∗13:02, HLA-DRB1∗11:01, HLA-DRB1∗04:05, HLA-DRB4∗01:01, HLA-DRB1∗10:01 | 99.53% |