Table 3.
Unadjusted | Adjusted | ||||
---|---|---|---|---|---|
HR (99% CI) | P value | HR (99% CI) | P value | ||
Marital status | Single (never married) | Reference | Reference | Reference | Reference |
Married | 0.78 (0.72–0.85) | <0.001 | 0.65 (0.57–0.74) | <0.001 | |
Divorced | 0.97 (0.86–1.10) | 0.566 | 0.89 (0.74–1.08) | 0.117 | |
Widowed | 1.59 (1.44–1.76) | <0.001 | 0.87 (0.74–1.01) | 0.019 | |
Age at diagnosis | 1.04 (1.04–1.04) | <0.001 | 1.05 (1.04–1.05) | <0.001 | |
| |||||
Sex | Female | Reference | Reference | Reference | Reference |
Male | 1.49 (1.40–1.58) | <0.001 | 1.33 (1.22–1.46) | <0.001 | |
| |||||
Insurance status | Insurance | Reference | Reference | Reference | Reference |
No insurance | 1.36 (1.16–1.58) | <0.001 | 1.76 (1.42–2.19) | <0.001 | |
| |||||
Race | White | Reference | Reference | Reference | Reference |
Black | 1.63 (1.21–2.20) | <0.001 | 1.66 (1.10–2.52) | 0.002 | |
Other | 0.83 (0.51–1.35) | 0.315 | 0.99 (0.51–1.93) | 0.966 | |
| |||||
Ethnicity | Non-Hispanic | Reference | Reference | Reference | Reference |
Hispanic | 1.29 (1.12–1.49) | <0.001 | 1.39 (1.13–1.71) | <0.001 | |
| |||||
Tobacco use | Never | Reference | Reference | Reference | Reference |
Current | 1.33 (1.21–1.46) | <0.001 | 1.461 (1.304–1.638) | <0.001 | |
Former | 1.36 (1.26–1.46) | <0.001 | 1.14 (1.05–1.25) | <0.001 | |
| |||||
Histology | Superficial spreading | Reference | Reference | Reference | Reference |
Acral lentiginous | 1.38 (1.19–1.60) | <0.001 | 1.10 (0.91–1.34) | 0.182 | |
Lentigo maligna | 2.22 (1.68–2.95) | <0.001 | 1.30 (0.91–1.86) | 0.055 | |
Nodular | 2.75 (2.41–3.14) | <0.001 | 1.56 (1.33–1.83) | <0.001 | |
Other | 1.54 (1.39–1.71) | <0.001 | 1.10 (0.97–1.25) | 0.046 | |
| |||||
Staging | Early | Reference | Reference | Reference | Reference |
Late | 4.32 (4.05–4.60) | <0.001 | 3.49 (3.18–3.82) | <0.001 | |
| |||||
Primary site | Face | Reference | Reference | Reference | Reference |
External ear | 1.06 (0.91–1.24) | 0.333 | 0.97 (0.78–1.19) | 0.664 | |
Scalp and neck | 1.18 (1.06–1.32) | <0.001 | 1.09 (0.94–1.26) | 0.142 | |
Trunk | 0.80 (0.73–0.87) | <0.001 | 1.00 (0.89–1.13) | 0.989 | |
Upper limb and shoulder | 0.82 (0.75–0.90) | <0.001 | 0.91 (0.80–1.02) | 0.034 | |
Lower limb and hip | 0.75 (0.68–0.83) | <0.001 | 0.85 (0.74–0.98) | 0.004 | |
| |||||
Geographic area | Northwest | Reference | Reference | Reference | Reference |
Northeast | 0.70 (0.60–0.82) | <0.001 | 0.66 (0.53–0.83) | <0.001 | |
North central | 0.72 (0.59–0.88) | <0.001 | 0.75 (0.56–0.99) | 0.009 | |
Central west | 0.77 (0.68–0.88) | <0.001 | 0.68 (0.56–0.84) | <0.001 | |
Central | 0.54 (0.47–0.62) | <0.001 | 0.57 (0.47–0.70) | <0.001 | |
Central east | 0.88 (0.76–1.02) | 0.025 | 0.77 (0.62–0.96) | 0.002 | |
Southeast | 0.75 (0.66–0.85) | <0.001 | 0.68 (0.56–0.83) | <0.001 | |
Southwest | 0.77 (0.67–0.90) | <0.001 | 0.67 (0.53–0.84) | <0.001 |
SD = standard deviation; ref = reference; HR = hazard ratio; CI = confidence interval. The races grouped under “others” consist of Micronesian, Chamorro/Chamoru, American Indian, Aleutia, Alaskan Native or Eskimo (includes all indigenous populations of the Western hemisphere), Chinese, Polynesian, Japanese, Tahitian, Filipino, Samoan, Hawaiian, Tongan, Korean, Melanesian, Vietnamese, New Guinean, Laotian, Other Asian, including Asian, not otherwise specified, Hmong, Pacific Islander, Kampuchean, Thai, Asian Indian or Pakistani, Asian Indian, Pakistani, Guamanian, Fiji Islanders, and Oriental, not otherwise specified, as well as unknown races. The histological categories grouped under “others” consist of Malignant Melanoma NOS, Balloon Cell Melanoma, Regressing Melanoma, Meningeal Melanomatosis, Amelanotic Melanoma, Melan Junction Nevus, Melan in Precanc Melanoma, Desmoplastic Melanoma, Mucosal Lentiginous Melan, Melan Giant Pig Nevus, Epithelioid/Spindle Cell Melan, Epithel Cell Melanoma, Spindle Cell Melanoma NOS, Spindle Cell Melanoma type A, Spindle Cell Melanoma type B, and Blue Nevus Malignant.