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. 2020 Apr 28;11:676. doi: 10.3389/fimmu.2020.00676

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Copyright © 2020 Xie, Wei and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treg cell recruitment into lung cancer. In NSCLC microenvironment, chemokines attract Tregs by binding to their corresponding receptors. Among them, DCs, macrophages and eosinophils are sources of CCL22, CCL17 is derived from DCs and lung cancer cells, CCL15 can be produced from lung cancer cells and MDCSs, lung cancer cells and stromal cells in NSCLC microenvironment are the major producers of CXCL12 and CCL20, respectively. Besides, CCL18 is generated from DCs and macrophages, lung cancer cells are responsible for CXCL1 and CCL28 production.