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. 2020 Apr 28;11:618. doi: 10.3389/fimmu.2020.00618

FIGURE 1.

FIGURE 1

Cellular anatomy of the liver sinusoid. Blood enters the liver from the portal vein and hepatic artery, flows through a network of sinusoids schematically represented here, and then exits via the hepatic central vein. The sinusoids are lined by a fenestrated layer of specialized liver sinusoidal endothelial cells (LSECs), which are the endogenous site of most FVIII secretion. The LSECs shield the hepatocytes from direct sinusoidal blood flow by creating the Space of Disse, which contains the stellate cells. Dendritic cells, Kupffer cells, T cells, natural killer (NK) cells, and natural killer T (NKT) cells are abundantly present in the sinusoidal lumen. Hepatic antigen presenting cells include dendritic cells, Kupffer cells, LSECs, stellate cells, and hepatocytes. The hepatocyte microvilli can interact with luminal T cells.