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. 2020 Apr 30;11:814. doi: 10.3389/fmicb.2020.00814

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Copyright © 2020 Xu, Lv, Guo, Li, Jia, Jiang, Wang, Zhang, Kong, Liu, Zhang, Lv and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gut microbiota induces specific changes in plasma lipids and metabolome. (A) PCA graphs of the plasma metabolome from QC samples in positive and negative metabolomics analysis. (B) PCA graphs of the plasma lipidome from all samples. (C) PCA of plasma metabolites from after PD-1 antibody treatment group mice. (D) Heatmap shows the normalized relative abundances of metabolites with annotation which were significantly changed in Control vs. Coli group and Vanc vs. Coli group. (E) Correlations between the gut microbiota (at the species level) and potential plasma compounds. Cells are colored based on Pearson correlation coefficient between predominant bacteria (relative abundance) and metabolites (normalized abundance) in plasma. The red color represents a significant negative correlation (P < 0.05), the blue color represents a significant positive correlation (P < 0.05).