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CR treatment regulated the expression of Nrf2, SOD1, HO-1, CAT, phospho-IκBα, and phospho-NF-κB in the kidney of db/db mice. Protein expression levels were normalized to the levels of GAPDH. The data were analyzed using a one-way ANOVA and expressed as mean ± SEM (n = 12). ###P < 0.001 versus db/+ mice, **P < 0.01 and ***P < 0.001 versus non-treated db/db mice.
