Table 3.

The effect of CR on the level of oxidative-related cytokines in the serum of db/db mice.

	db/m+	db/db	db/db+Met (100 mg/kg)	db/db+CR (50 mg/kg)
ROS (U/mL)	329.3 ± 32.6	458.0 ± 42.3##	306.3 ± 34.5**	347.2 ± 37.9*
MDA (nmol/mL)	42.4 ± 5.2	68.8 ± 5.6###	49.2 ± 4.5**	50.3 ± 5.2*
SOD (U/mL)	120.8 ± 11.0	87.5 ± 9.5##	106.9 ± 9.9*	110.1 ± 9.3*
CAT (U/mL)	121.8 ± 11.5	52.1 ± 6.0###	78.6 ± 8.2**	70.9 ± 6.9**
GSH-Px (U/mL)	178.7 ± 14.5	143.8 ± 13.6#	171.2 ± 16.9*	178.9 ± 15.0*

The data were analyzed using a one-way ANOVA and expressed as means ± SEMs (n = 12). ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001 versus db/m+ mice, *P < 0.05 and **P < 0.01 versus non-treated db/db.